Population-Based Case-Control Study of Antidepressants in Early and Average-Age Onset Colorectal Cancer: The Impact of Exposure Window, Class, Dose, and Intensity.

ABSTRACT:

Background

Given inconsistent findings from previous epidemiologic studies on the association between antidepressant exposure and colorectal cancer (CRC), our study provides a rigorous investigation to clarify the temporality of this association, including early-age onset (EAO) and average-age onset (AAO) CRC.

Methods

We conducted a population-based case-control study using administrative health databases from British Columbia, Canada. We included CRC cases and controls, matched (1:10) on age, sex, and index date (i.e., CRC diagnosis date/matched date). Antidepressant exposures were ascertained by duration (i.e., varying windows from 15 to 1 year before CRC diagnosis), drug classes (tricyclic antidepressants (TCAs), selective serotonin reuptake inhibiters (SSRIs), other), cu

SUBMITTER: Cheng V 

PROVIDER: S-EPMC12754579 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature