A metabolomics study reveals potential plasma biomarkers for predicting post-infarction left ventricular remodeling: findings from the metabolights database.

ABSTRACT:

Background

Left ventricular remodeling (LVR) after ST-segment elevation myocardial infarction (STEMI) is a major determinant of adverse prognosis, yet reliable early biomarkers remain limited.

Methods

This secondary analysis of publicly available metabolomic data from the MetaboLights database aimed to explore metabolic signatures associated with left ventricular remodeling (LVR) following STEMI patients. Key differential metabolites were identified through an integrated approach combining multivariate screening (PLS-DA with VIP >1.0) and univariate validation (Log2FC, FDR, Cohen's d). The robustness of principal findings was further verified by bootstrap resampling. These metabolites subsequently underwent comprehensive evaluation through univariate testing, ROC analysis, a

SUBMITTER: Chen D 

PROVIDER: S-EPMC12754600 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature