CcpA promotes <i>Staphylococcus aureus</i> virulence by directly controlling staphyloxanthin production.

ABSTRACT: Staphylococcus aureus is a notorious opportunistic pathogen with remarkable adaptability, enabling it to infect virtually every human tissue. Staphyloxanthin (STX), a critical virulence factor, contributes to S. aureus oxidative damage. However, the regulatory mechanism of STX production is incompletely understood. This study provides mechanistic insights into the role of catabolite control protein A (CcpA) in STX production. ccpA deletion considerably reduced STX yield in S. aureus strains with diverse genetic lineages. Western blot showed that CcpA inactivation did not alter SigB expression levels in S. aureus. Gene reporter and electrophoretic mobility shift assays revealed the direct control of CcpA on the expression of the crtOPQMN operon, whi

SUBMITTER: Chen X 

PROVIDER: S-EPMC12754628 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature