Cytokine and Endothelial Activation Patterns Related to Severe and Non-Severe Respiratory Viral Infections.

ABSTRACT: Respiratory viral infections (RVIs) are a major cause of global morbidity and mortality. Severe cases are driven by dysregulated inflammation, impaired interferon (IFN) responses, and thromboinflammation, yet the mechanisms underlying endothelial dysfunction remain poorly defined. We collected 234 leftover material samples from hospitalized patients with PCR-confirmed RVIs. Patients were stratified by viral etiology, differential involvement of the respiratory tract, age and possible co-infections. Cytokines (IL-6, IL-8, IL-1β, TNF-α), IFNs (α/β/γ), and endothelial markers (ICAM-1, VCAM-1) were quantified using microfluidic immunoassays. Routine coagulation parameters were measured in a subset of patients. Compared with controls, RVI patients exhibited significantly elevated systemic cytok

SUBMITTER: Ferrarese R 

PROVIDER: S-EPMC12754636 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature