Accelerated Brain Aging, Atherogenicity, and Neurocognition in Adult Survivors of Childhood Cancer.

ABSTRACT:

Importance

Long-term survivors of childhood cancer may be at elevated risk for accelerated brain aging.

Objectives

To determine the brain age gap estimation (BrainAGE), defined as the difference between estimated brain age and chronological age; the association between BrainAGE scores and poor neurocognitive outcomes; and the correlations of plasma biomarkers of oxidative stress, neuroinflammation, and cardiovascular health with older BrainAGE scores and previous exposure to central nervous system-directed therapy in adult survivors of childhood cancer.

Design, setting, and participants

This cross-sectional study analyzed participants in the St. Jude Lifetime Cohort Study. Included participants were survivors of childhood cancer (brain tumor, acute lymphoblastic leuke

SUBMITTER: Phillips NS 

PROVIDER: S-EPMC12754683 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature