Photodynamic Antibacterial Nanofibers with Tunable Pro- and Antioxidant Activity via N,S-Doped Carbon Quantum Dots for Corneal Tissue Engineering.

ABSTRACT: Antibiotic resistance poses a critical challenge in ocular medicine, where treatments must combine antibacterial potency with tissue compatibility. Electrospun core-shell nanofibers offer an attractive solution for ocular applications as they provide a biomimetic extracellular matrix structure with controlled drug release and surface functionality. In this work, polycaprolactone (PCL) was used as the mechanically robust, biodegradable core, while polyvinylpyrrolidone (PVP) formed a hydrophilic shell to enhance wettability and ocular compatibility. The nanofibers were further functionalized with N,S-doped carbon quantum dots, exhibiting light-switchable redox behavior. Compositional and spectroscopic analyses revealed that N,S-doped CQDs possessed a significantly narrowed bandgap (3.14 eV)

SUBMITTER: Kurpanik R 

PROVIDER: S-EPMC12754744 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature