Brush-like Polymer Surface on Silk Fibroin Films for Controlled Release of Local Anesthetics.

ABSTRACT: Postsurgical pain management remains a persistent challenge for patients and healthcare providers. This work presents an implantable, degradable drug release platform based on silk biomaterials designed to be placed at a desired surgical site intraoperatively to release the local anesthetic bupivacaine in a sustained manner to prevent and treat postsurgical pain. Methacrylate monomers containing different pendant groups are used to generate brush-like polymers on silk fibroin films by surface-initiated reversible addition-fragmentation chain transfer polymerization. These brushes have side groups to control polymer hydrophilicity and facilitate drug attachment via a hydrolyzable tether. Spectroscopy and contact angle goniometry are used to characterize the chemical composition and hydropho

SUBMITTER: Patil SA 

PROVIDER: S-EPMC12754761 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature