Body mass index modifies the association between transthyretin concentrations and gestational diabetes mellitus across pregnancy trimesters.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM), an increasingly prevalent pregnancy complication, poses significant risks to both maternal and fetal health. Early detection and management are crucial, yet current biomarkers for GDM screening are limited. In this context, the present study aims to explore the association between plasma transthyretin (TTR) concentrations and GDM development as well as the interaction between TTR and maternal body mass index (BMI) on the risk of GDM across trimesters.

Methods

A retrospective cohort study included 12,893 pregnant women from the Second Affiliated Hospital of Wenzhou Medical University. Multivariate restricted cubic spline (RCS) models and logistic regression were used to analyze the relationship between TTR concentrations, matern

SUBMITTER: Hou H 

PROVIDER: S-EPMC12754908 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature