Prognostic value of manual and digital PD-L1 expression in pT3 and pT4 colon cancer.

ABSTRACT:

Background

Programmed death ligand 1 (PD-L1) is a prognostic marker in several malignancies, but the prognostic value of PD-L1 expression in colorectal cancer (CRC) is inconclusive. Lack of standardized scoring systems for PD-L1 evaluation in CRC has led to inconsistent findings. This exploratory study aimed to evaluate PD-L1 expression using manual and digital methods and correlate the results to overall survival (OS) in a cohort of patients with pT3 and pT4 colon cancer (CC).

Methods

From a previously published study, 162 patients with pT3 and pT4 CC were included. One tumor slide representing the invasive margin was selected and stained for PD-L1 (22C3). PD-L1 was evaluated according to the tumor proportion score (TPS), the immune cell score (ICS), and the combined positi

SUBMITTER: Jepsen DNM 

PROVIDER: S-EPMC12754915 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature