Per- and polyfluoroalkyl substances (PFAS) exposure and cardiovascular risk: lipid profile as a mediator.

ABSTRACT:

Background

In recent years, amidst the phase-out of long-chain per- and polyfluoroalkyl substances (PFAS), the true relationship between PFAS exposure and lipid metabolism or cardiovascular disease (CVD), as well as the role of lipid profiles in this association, remains unclear.

Methods

Data from 25 531 NHANES participants (age ≥ 20 years old) enrolled between 2015 and 2020 were examined. To assess links between individual PFAS and cardiovascular disease (CVD) as well as lipid measures, both logistic and multivariable linear regression analyses were performed. Nonlinear exposure-response patterns with CVD were fitted using restricted cubic splines. In addition, the combined impact of PFAS mixtures on CVD risk was investigated via Bayesian kernel machine regression (BKMR), w

SUBMITTER: Wang X 

PROVIDER: S-EPMC12754923 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature