Sustained hippocampal neuroinflammation and subsequent glutamatergic dysfunction in juvenile idiopathic arthritis: evidence from proton magnetic resonance spectroscopy (¹H-MRS).

ABSTRACT:

Background

Chronic pain and psychiatric comorbidities in juvenile idiopathic arthritis (JIA) persist even during disease remission, suggesting central nervous system (CNS) alterations. This study used proton magnetic resonance spectroscopy (¹H-MRS) to investigate neurometabolic changes in the right hippocampus of JIA patients across active and inactive disease phases.

Methods

A cohort of 248 JIA patients (61 treatment-naïve patients with active JIA and 187 patients with inactive JIA) and 57 healthy controls (HCs) underwent ¹H-MRS of the right hippocampus. Metabolite ratios of total N-acetylaspartate (tNAA), total choline (tCho), myo-inositol (mI), glutamate (Glu), and glutamate-glutamine complex (Glx) relative to total creatine (tCr) were quantified. As

SUBMITTER: Han H 

PROVIDER: S-EPMC12754929 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature