Mesenchymal stem cell-derived apoptotic extracellular vesicles loaded with Prussian blue nanoparticles attenuate severe acute pancreatitis via neutrophil extracellular traps resolution and acinar-ductal metaplasia promotion.

ABSTRACT: Nowadays, severe acute pancreatitis (SAP) remains a critical clinical disease with a high mortality rate. Current treatments are mainly supportive, lacking specific therapies targeting the core pathological mechanisms including neutrophil extracellular traps (NETs)-mediated systemic inflammation and progressive acinar cell necrosis, which may lead to many complications. Therefore, in this study, we developed a novel dual-targeting nanodrug delivery system named PBs@CCR2-ApopEVs, combining Prussian blue nanoparticles (PBs) and CCR2-overexpressing mesenchymal stem cell-derived apoptotic extracellular vesicles (ApopEVs). Through the specific binding of CCR2 with numerous CCL2 released by neutrophils in SAP, the PBs@CCR2-ApopEVs can be actively recruited to the pancreatic inflammation site. Th

SUBMITTER: Xu W 

PROVIDER: S-EPMC12755009 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature