Profiling phagosome proteins identifies PD-L1 as a fungal-binding receptor.

ABSTRACT: Phagocytosis is the process by which myeloid phagocytes bind to and internalize potentially dangerous microorganisms¹. During phagocytosis, innate immune receptors and associated signalling proteins are localized to the maturing phagosome compartment, forming an immune information processing hub brimming with microorganism-sensing features^2-8. Here we developed proximity labelling of phagosomal contents (PhagoPL) to identify proteins localizing to phagosomes containing model yeast and bacteria. By comparing the protein composition of phagosomes containing evolutionarily and biochemically distinct microorganisms, we unexpectedly identified programmed death-ligand 1 (PD-L1) as a protein that specifically enriches in phagosomes containing yeast. We found that PD-L1 direc

SUBMITTER: Li K 

PROVIDER: S-EPMC12755075 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature