Screening and targeted prophylaxis for Clostridioides difficile infection.

ABSTRACT:

Objective

Patients receiving immunosuppression for oncology treatment and solid organ transplantation are at high risk for developing hospital-onset Clostridioides difficile infection (HO-CDI). We studied the impact of a prophylactic enteral vancomycin intervention on the reduction of HO-CDI during high-risk inpatient admissions among immunocompromised patients.

Methods

The screening and targeted prophylaxis (STOP) intervention was implemented over a 2-year period. Patients admitted for solid organ transplant, autologous stem cell transplant, chimeric antigen receptor T-cell, or treatment for leukaemia were screened for colonization with C. difficile. Colonized patients were placed in contact isolation and were advised to start anti-C.difficile antibiotic prophylaxis. To ass

SUBMITTER: Ziegler MJ 

PROVIDER: S-EPMC12755115 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature