Verification and Validation of an Autotuning Proportional-Integral-Derivative Controller for Spatially Confined Magnetic Particle Hyperthermia.

ABSTRACT: We have previously verified the capabilities of a prototype magnetic nanoparticle (MNP) heater (called HYPER) that can perform spatially confined heating; however, the design lacked temperature control capabilities. In this work, we designed, verified, and validated a relay-based autotuning proportional-integral-derivative (PID) controller to be used with the HYPER during in vivo experiments. The PID controller is an autotuning, relay-based controller with several design constraints: The controller must: (1) maintain tumor temperature within hyperthermic range of 41-46 °C; (2) rise time ≤ 5 min; (3) steady-state temperature must be within ±0.5 °C of the setpoint; (4) standard deviation of steady-state temperature within ±0.5 °C; and (5) temperature overshoot within 5%. The relay-based auto

SUBMITTER: Pawar S 

PROVIDER: S-EPMC12755161 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature