The acute myeloid leukemia microenvironment impairs neutrophil maturation and function through NF-κB signaling.

ABSTRACT:

Abstract

Acute myeloid leukemia (AML), an aggressive hematological malignancy, is driven by oncogenic mutations in stem and progenitor cells that give rise to AML blasts. Although these mutations are well characterized, their impact on healthy hematopoiesis, those blood cells exposed to AML but not mutated, has not been well characterized. Because the marrow is the major site for granulopoiesis, neutrophils are heavily influenced by AML pathobiology. Indeed, most patients with AML report neutropenia, rendering them susceptible to infections. However, because AML studies use peripheral blood mononuclear cells devoid of neutrophils, the characterization of neutrophil dysfunction remains poorly understood. To investigate AML-exposed neutrophils, a preclinical AML mouse model in which

SUBMITTER: Goel P 

PROVIDER: S-EPMC12755217 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature