Brief Report: Is Gestational Exposure to HIV and Protease Inhibitors Associated With Timing of Pubertal Onset?

ABSTRACT:

Background

Few studies have evaluated the influence of gestational HIV/antiretroviral exposure on pubertal onset in children who are HIV-exposed but uninfected (CHEU).

Methods

CHEU in the Surveillance Monitoring for ART Toxicities study and children HIV-unexposed uninfected (CHUU) in the Bone Mineral Density in Childhood Study with Tanner staging at age 9 years were included. Pubertal onset was defined as Tanner stage ≥2 for each sex-specific puberty indicator. Log-binomial regression models were fit to estimate relative risks (RRs) of pubertal onset in CHEU vs. CHUU, adjusted for exact age and other covariates. Among CHEU, models were fit to assess the association of pubertal onset with maternal protease inhibitor exposure, CD4 count, and earliest HIV viral load (VL) during

SUBMITTER: Serghides L 

PROVIDER: S-EPMC12755235 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature