Low-Frequency Adaptive Deep Brain Stimulation for Parkinson's Disease.

ABSTRACT:

Background

Freezing of gait (FOG) is a debilitating symptom of Parkinson's disease (PD) that often worsens with disease progression. Adaptive deep brain stimulation (aDBS) may better target symptom fluctuations and gait impairment, yet most studies have focused on high-frequency stimulation. Low-frequency stimulation may offer additional gait benefits in moderate-to-advanced PD.

Objective

To evaluate the efficacy of 60 Hz continuous DBS (cDBS) and the safety, tolerability and feasibility of 60 Hz aDBS.

Methods

Eight individuals with PD were implanted with bilateral leads in the subthalamic nucleus and the investigational Summit RC+S system (Medtronic, Inc.). 60 Hz aDBS was calibrated to adjust stimulation amplitude based on prolonged beta bursts. Participants complete

SUBMITTER: Negi AS 

PROVIDER: S-EPMC12755257 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature