Mapping the prevalence of molecular markers of <i>Plasmodium falciparum</i> artemisinin partial resistance in Africa: a spatial-temporal modelling study.

ABSTRACT:

Background

Plasmodium falciparum kelch13 (k13) mutations in Africa signal emerging artemisinin partial resistance (ART-R), endangering malaria control by undermining artemisinin-based combination therapies (ACTs). Sparse surveillance obscures whether rising k13 ART-R prevalence reflects local emergence or geographic expansion. We aimed to model and infer high-resolution spatial-temporal prevalence of k13 ART-R and ACT partner-drug markers to inform public health policy.

Methods

We conducted a systematic literature review (PROSPERO-ID CRD42024593923) spanning the years 2014-2025, complementing existing data from WWARN, MalariaGEN Pf7, and the WHO Malaria Threats Map. This integrated dataset, comprising 3,806 distinct molecular epidemiology surveys

SUBMITTER: Young NW 

PROVIDER: S-EPMC12755267 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature