The Clinical Characteristics and Treatment of Patients With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy (GFAP-A): A Retrospective Study of 29 Patients.

ABSTRACT:

Purpose

To investigate the clinical features, treatment, and outcome of patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A).

Methods

Medical records and collected case data from the First Affiliated Hospital of Zhejiang University School of Medicine from November 2020 to May 2024 and retrospectively analyzed the clinical features, radiological findings, laboratory findings, treatment, and outcomes of patients with autoimmune GFAP-A.

Results

Twenty-nine eligible patients were included, predominantly male (21/29), with acute onset in 17 patients (58.6%). Common clinical syndromes included encephalitis, meningoencephalitis, encephalomyelitis, meningoencephalomyelitis, and myelitis. Magnetic resonance imaging (MRI) of the brain revealed widesp

SUBMITTER: Yang X 

PROVIDER: S-EPMC12755398 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature