Radiomic features derived from pretherapeutic MRI predict chemoradiation response in locally advanced rectal cancer.

ABSTRACT:

Background

The standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant concurrent chemoradiotherapy (CRT) followed by surgical excision. Current evidence suggests a favorable prognosis for those with pathological complete response (pCR), and surgery may be spared for them. We trained and validated regression models for CRT response prediction with selected radiomic features extracted from pretreatment magnetic resonance (MR) images to recruit potential candidates for this watch-and-wait strategy.

Methods

We retrospectively enrolled patients with LARC who underwent pre-CRT MR imaging between 2010 and 2019. Pathological complete response in surgical specimens after CRT was defined as the ground truth. Quantitative features derived from both unfiltered and f

SUBMITTER: Chou Y 

PROVIDER: S-EPMC12755438 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature