Targets of total glucosides of paeony in the treatment of Sjogren syndrome: A network pharmacology study.

ABSTRACT:

Background

We aimed to explore the underlying mechanism of the total glucoside of peony (TGP) in treating Sjogren syndrome (SS) using the network pharmacology approach.

Methods

The protein targets of TGP and SS were identified by database search. Then, the intersection of the two groups was studied. The drug-target network between TGP and the overlapping genes was constructed, visualized, and analyzed by Cytoscape software. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment were performed to analyze these genes. Finally, the predictions of potential targets were evaluated by docking study.

Results

Forty-six overlapping genes were discovered. The results suggested that TGP used in the treatment of SS is associated with cellular tumor antigen p53, neur

SUBMITTER: Xiao L 

PROVIDER: S-EPMC12755574 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature