Associations of Plasma Lipids with Traumatic Brain Injury Outcomes: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study.

ABSTRACT: Hypocholesterolemia has been observed in acute trauma, but less is known about lipid levels in acute traumatic brain injury (TBI). Our objectives were to (1) compare day 1 post-injury lipid levels from individuals with acute TBI to orthopedic trauma and healthy controls and (2) investigate associations of day 1 post-TBI lipid levels with clinical outcomes over the first-year post-injury. A subset of 266 participants with TBI, 68 orthopedic trauma controls, and 58 healthy controls from the Transforming Research and Clinical Knowledge in TBI Study were included in analyses. Plasma total cholesterol and triglycerides were measured using the enzymatic colorimetric method, and high-density lipoprotein (HDL) was measured via direct homogeneous/enzymatic colorimetric methods. Low-density lipoprot

SUBMITTER: Schneider ALC 

PROVIDER: S-EPMC12755847 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature