Integrative linkage and recombination analysis of 25 X-STRs across 7 linkage groups using pedigree-based and SNP-based strategies.

ABSTRACT:

Introduction

X-chromosomal short tandem repeats (X-STRs) are valuable genetic markers in forensic science for resolving complex kinship scenarios. However, the linkage relationship and recombination of X-STRs remain poorly characterized.

Methods

Based on high-density SNP data with relatively low mutation rates, we developed a pedigree-based method to analyze the recombination relationships between these X-STR linkage groups (LGs). We used X-STRs data from 66 two-generation families and X-SNPs data from 602 X-chromosomal SNP trios from the 1000 Genomes Project. We investigated the linkage relationships among 25 X-STR loci, grouped into seven LGs, including three identified regions (Xp21.1, Xq21.31, Xq23) and four Argus X-12 (Xp22.2, Xq12, Xq26, Xq28), provided broader coverag

SUBMITTER: Qian J 

PROVIDER: S-EPMC12755858 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature