Post-translational modification gene signatures implicate FBXW7 in immune and vascular dysregulation of Moyamoya disease.

ABSTRACT:

Background

Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive stenosis and occlusion of intracranial arteries and abnormal collateral vessel formation. However, the underlying molecular mechanisms are not completely understood. Post-translational modifications (PTMs) are essential regulators of protein function and signal pathway, yet their roles in MMD have not been fully explored.

Methods

Transcriptomic datasets from an independent cohort and public datasets were integrated. Differential expression analysis, weighted gene co-expression network analysis (WGCNA), and machine learning were applied to identify candidate biomarkers. Functional enrichment, immune infiltration analysis, and protein-protein interaction networks were constructed.

SUBMITTER: Yu X 

PROVIDER: S-EPMC12755860 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature