Cortically Dependent Motor Training Does Not Induce Abnormal Movements in DYT1-Knock In Mice.

ABSTRACT:

Purpose

DYT1 dystonia is the most common inherited dystonia, but mouse models recapitulating the human genotype do not exhibit overtly dystonic movements. Because cortical and striatal plasticity are implicated in dystonia pathogenesis, we hypothesized that repetitive performance of a cortically-dependent reach-to-grasp task would induce abnormal dystonia-like movements in DYT1-knock in (DYT-KI) mice. The goal of these experiments was to test that hypothesis.

Methods

TorsinA ΔE (DYT1-KI) mutant mice and non-transgenic littermates (control) were trained to perform a cortically-dependent single pellet reach-to-grasp task using an automated skilled reach-to-grasp apparatus. Task performance and the presence of abnormal movements were manually scored by reviewers blinded to geno

SUBMITTER: Hodge AT 

PROVIDER: S-EPMC12755967 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature