Distinct Gut Microbiota Profiles Reflect Severity in Chronic Insomnia Disorder.

ABSTRACT:

Introduction

Severe insomnia symptoms increase the risk of persistent sleep disorders, underscoring the need for timely identification to optimize therapeutic interventions. Given the established association between chronic insomnia disorder (CID) and gut microbiota, this study aimed to evaluate the utility of gut microbiota characteristics for stratifying CID severity.

Methods

A total of 65 patients with CID were categorized into two groups based on Pittsburgh Sleep Quality Index (PSQI) scores: S-CID (more severe poor sleep quality; median age: 36, IQR: 30-47; M/F: 12/22) and M-CID (milder poor sleep quality; median age: 33, IQR: 25-43; M/F: 11/20). Thirty healthy controls (HC; median age: 32, IQR: 26-48; M/F: 8/22) were also included. All participants underwent polysomnogr

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12755969 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature