Molecular mechanisms of human papillomavirus-induced tongue carcinogenesis: A systematic review.

ABSTRACT:

Background

Human papillomavirus (HPV) infection has emerged as a significant etiological factor in tongue cancer, particularly among individuals without conventional risk factors such as tobacco or alcohol use. Understanding the molecular mechanisms underlying HPV-induced tongue carcinogenesis is critical for advancing targeted interventions.

Objective

To systematically review existing literature on genetic and epigenetic alterations in HPV-associated tongue cancer, with emphasis on viral oncoprotein interactions, disrupted cellular signalling pathways, and immune evasion mechanisms.

Data sources

Electronic databases searched included PubMed, Scopus, Web of Science, Dentistry and Oral Sciences Source, and AMED.

Methods

A systematic search using relevant MeSH te

SUBMITTER: Kodikarage CH 

PROVIDER: S-EPMC12755974 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature