Emergence and genomic characterization of mcr-8.2-positive Klebsiella pneumoniae from layer chickens in Xinjiang, China.

ABSTRACT: Klebsiella pneumoniae as a conditional pathogen has become a worldwide public health issue. It can colonize animals and is capable of transmitting to humans through the food chain, raising serious concerns about antimicrobial resistance (AMR). In this study, the prevalence, phenotypes, genomic characteristics of K. pneumoniae in layer chicken feces were investigated across five regions of Xinjiang, China. From 1115 samples collected, 408 (36.6%) K. pneumoniae were isolated. Antimicrobial susceptibility testing revealed the highest resistance rates to colistin (55.0%) and florfenicol (50.0%). PCR results revealed high detection rate of plasmid-mediated quinolone resistance (PMQR) genes, with oqxA (97.8%) and oqxB (90.4%) being the most prevalent. Among β-lactam-resistance genes, bla_SHV

SUBMITTER: Tian R 

PROVIDER: S-EPMC12756032 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature