The association of Alzheimer's disease and related dementias blood-based biomarkers with depressive symptoms.

ABSTRACT:

Introduction

Depressive symptoms are common in older adults and have been associated with the risk of Alzheimer's disease/Alzheimer's disease and related dementias (AD/ADRD), but the mechanisms and biomarkers underlying this association remain unclear.

Methods

We included baseline data from 11,947 non-demented adults aged ≥ 70 years at enrollment in the Aspirin in Reducing Events in the Elderly (ASPREE) clinical trial. Linear regressions were used to examine cross-sectional associations between AD/ADRD blood-based biomarkers (BBMs) and baseline depressive symptoms. Interactions between sex or apolipoprotein E (APOE) ε4 carrier status and BBMs were examined.

Results

Higher glial fibrillary acidic protein (GFAP) was associated with higher depressive symptoms. We did not

SUBMITTER: Bacci JR 

PROVIDER: S-EPMC12756043 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature