Global burden of ovarian cancer attributable to high body mass index among women of childbearing age from 1990 to 2021 and projections to 2050: a systematic analysis for the global burden of disease study 2021.

ABSTRACT:

Background

Ovarian cancer (OC) remains a lethal gynecologic cancer marked by substantially reduced 5-year survival probabilities. Elevated BMI (≥25 kg/m²) constitutes a progressively recognized OC risk determinant mediated by chronic inflammatory states and metabolic pathway perturbations. Leveraging GBD 2021 repositories, this investigation quantified high BMI-attributable ovarian cancer burden trajectories among reproductive-age women (WCBA, 15-49 years) worldwide.

Methods

Leveraging GBD 2021 repositories, we evaluated worldwide OC burden mediated by elevated BMI across women of childbearing age (WCBA) during 1990-2021. Evaluated metrics comprised deaths, DALYs, YLDs, YLLs, and ASR (EAPC-based trend analysis). ARIMA and Exponential Smoothing models generated 2050 burden pr

SUBMITTER: Chen H 

PROVIDER: S-EPMC12756064 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature