Prognostic value of the relative neutrophil-monocyte-to-lymphocyte-albumin ratio in chronic lower respiratory diseases: a multicenter retrospective analysis.

ABSTRACT:

Background

Chronic lower respiratory diseases (CLRDs) remain major causes of global mortality. Because conventional inflammatory markers have limited prognostic utility, we developed and validated the relative neutrophil-monocyte-lymphocyte-albumin ratio (NMLAR), defined as (Neutrophil% × Monocyte% × 100)/(Lymphocyte% × Albumin [g/dL]), as a novel biomarker to predict CLRD-specific mortality.

Methods

Immune infiltration of CLRDs was analyzed based on GEO datasets. We then analyzed 9,236 adults with CLRD from NHANES 1999-2014, excluding individuals with missing core variables. Machine learning algorithms (Boruta, SVM-RFE, XGBoost) were applied to identify key predictors. Cox proportional hazards models and restricted cubic spline (RCS) functions were used to evaluate the asso

SUBMITTER: Chen X 

PROVIDER: S-EPMC12756091 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature