Multi-omics profiling unravel the immune landscape diversity by prognostic signatures of immunotherapy response in triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) remains a challenging malignancy with limited therapeutic options and variable responses to immune checkpoint inhibitors (ICIs). The tumor immune infiltration significantly influences the outcomes of immunotherapy treatments. Novel biomarkers are urgently needed which integrate both tumor-intrinsic and immune-related features to better stratify patients and dissect the immune microenvironment.

Methods

We investigated the tumor immune infiltration and assessed its prognostic significance in an internal cohort of TNBC patients using multiplex immunofluorescence. Then we integrated multi-omics approach that combines bulk and single-cell RNA sequencing to develop a prognostic signature. The model underwent validation across three i

SUBMITTER: Chai R 

PROVIDER: S-EPMC12756148 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature