Maternal urinary metabolomic signatures preceding spontaneous preterm birth: A pilot study.

ABSTRACT: The etiological heterogeneity of spontaneous preterm birth (sPTB) complicates PTB risk prediction and management. Accurate risk stratification at clinical suspicion is critical to administer life-saving interventions for fetuses at genuine risk, while avoiding unnecessary treatments in pregnancies progressing to term to mitigate long-term complications. Current tools lack predictive accuracy, with 40% of suspected PTB delivering at term. This pilot study investigated signaling lipids as potential biomarkers for sPTB. Prospectively collected midstream urine of 30 women with imminent PTB were retrospectively classified into preterm without chorioamnionitis, preterm with chorioamnionitis, and term, and analyzed using liquid-chromatography mass-spectrometry. Overall-preterm vs. term analysis r

SUBMITTER: Thangavelu MU 

PROVIDER: S-EPMC12756231 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature