Activation/inactivation of Tregs mediated by Kv1.3 potassium channels synergistically with exosome secretion to regulate myocardial fibrosis.

ABSTRACT: Transforming growth factor-β (TGF-β) can promote myocardial fibrosis (MF). However, it was reported that regulatory T cells (Tregs) can reverse MF via secretion of anti-inflammatory cytokine IL-10. At present, the pathway of pro-myocardial fibrosis factors secreted by Tregs cells is not clear. Kv1.3 channel is closely related to the activation of Treg cells, which is a potential target for immuno-regulation. Here, we investigated whether the communication between co-cultured cells of Tregs and cardiac fibroblasts (CFs) was affected by the reduction of TGF-β secreted from Tregs by Kv1.3 knockdown, as well as whether exosome pathway mediates the pro-myocardial fibrosis process of Tregs. After co-culturing of Tregs transfected by RNA interference Kv1.3 potassium channel with CFs, we measured

SUBMITTER: Li M 

PROVIDER: S-EPMC12756267 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature