Immunity to six vaccine pathogens in HIV positive and HIV negative children in Equatorial Guinea.

ABSTRACT: Vaccination prevents millions of childhood deaths annually, yet 23 million infants still miss essential vaccines, mostly in Sub-Saharan Africa. Low coverage is particularly concerting in countries with high paediatric HIV prevalence. In Equatorial Guinea, where 6% of children live with HIV and vaccination coverage remains limited, information on vaccine-induced immunity is scarce. We conducted a cohort study to evaluate immunity against six vaccine-preventable diseases in HIV-exposed children from Bata. Plasma samples from 69 children (55 HIV+/14 exposed uninfected) collected between 2019 and 2021 were analysed by a chemiluminescent immunoassay. Despite antiretroviral therapy, only 18.5% of HIV + children achieved viral suppression. Reported vaccination coverage for DTP and measles was low

SUBMITTER: Rodriguez-Galet A 

PROVIDER: S-EPMC12756303 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature