Structural insights into AVR-Rmg8 recognition mechanisms by the wheat blast resistance gene Rmg8.

ABSTRACT: Wheat blast disease, caused by the Triticum pathotype of Magnaporthe oryzae (MoT), poses a significant threat to global food security. The blast resistance gene Rmg8, recently isolated from a hexaploid wheat cultivar, strongly confers resistance to all Bangladeshi and Zambian MoT isolates that carry the eI type of AVR-Rmg8. However, the molecular interactions underlying this recognition at the protein level remain poorly understood. In this study, we elucidated the structural and biological characteristics of RMG8 proteins and their recognition of the AVR-Rmg8 effector proteins using computational biology approaches. Amino acid sequence comparison of four AVR-Rmg8 types revealed that only three amino acid residues distinguish the eI type of AVR-Rmg8, which induces a higher level of resista

SUBMITTER: Hasnat S 

PROVIDER: S-EPMC12756323 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature