Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration.

ABSTRACT: The rapid advancement of DNA sequencing technologies and computational algorithms has led to an unprecedented surge in genomic data, driven by several large-scale sequencing projects worldwide. Orthology plays a crucial role in understanding evolutionary patterns of genes and their functions. At the last Quest for Orthologs meeting (Montréal, Canada-2024), we discussed recent advances in orthology inference, with a focus on the impact of artificial intelligence (AI), protein structures, RNA splicing isoforms, and protein domain evolution together with other evolutionary considerations. A long-standing challenge in the field is the functional annotation of paralogs, for which we present novel approaches. The meeting also emphasised strategies for integrating diverse genetic features into th

SUBMITTER: Majidian S 

PROVIDER: S-EPMC12756340 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature