Synergistic antitumor effects of <i>astragalus</i> polysaccharide: a preclinical systematic review and meta-analysis.

ABSTRACT:

Background

Accumulating evidence suggests that astragalus polysaccharide (APS) may enhance the efficacy of conventional cancer therapies through multiple mechanisms. However, the synergistic effects of APS have not been systematically quantified. This meta-analysis was therefore conducted to quantify these potential synergistic antitumor effects and provide preclinical evidence to inform future clinical trials.

Methods

Following PRISMA 2020 guidelines, we systematically searched ten databases (including PubMed and Web of Science) for preclinical studies from inception to May 2025 using predefined inclusion criteria. Risk of bias was assessed using SYRCLE's RoB tool. Meta-analyses and subgroup analyses were performed using RevMan 5.4.1, while publication bias was assessed via

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12756362 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature