Serum CHI3L1 levels correlate with disease activity in rheumatoid arthritis and reveal potential molecular mechanisms.

ABSTRACT:

Objective

This study aims to elucidate the molecular regulatory mechanisms of Chitinase-3-like protein 1 (CHI3L1) in rheumatoid arthritis (RA) and its association with disease activity, focusing on its translational potential in RA diagnosis, dynamic monitoring, and precision therapy.

Methods

Transcriptomic datasets (GSE77298, GSE89408) and single-cell RNA-seq data (GSE200815) were obtained from Gene Expression Omnibus (GEO). CHI3L1 expression was analyzed by Wilcoxon test, and diagnostic accuracy by Receiver Operating Characteristic (ROC) curve. Single-cell analysis defined cell type-specific expression of CHI3L1. Differential analysis combined with weighted gene co-expression network analysis (WGCNA) identified CHI3L1-related genes, followed by protein-protein interaction

SUBMITTER: Deng Y 

PROVIDER: S-EPMC12756385 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature