Inflammation centered muscle signature of sarcopenia from postmenopausal women in Shanghai China.

ABSTRACT:

Introduction

Sarcopenia reflects age-related failure of muscle maintenance and regeneration, with chronic low-grade inflammation disrupting the satellite cell niche. Validated tissue biomarkers that connect inflammaging to clinical phenotypes remain limited. We sought to define an inflammation-centered muscle transcriptomic signature in postmenopausal women from Shanghai China and to assess its association with case-control status and muscle phenotypes.

Methods

We prospectively enrolled 20 women undergoing femoral fracture surgery including sarcopenia (n = 8) and controls (n = 12). Vastus lateralis biopsies underwent RNA sequencing. Differentially expressed genes were identified and intersected with inflammation-associated genes from GeneCards. Random-forest models prioritiz

SUBMITTER: Fan Y 

PROVIDER: S-EPMC12756426 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature