Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations.

ABSTRACT:

Background

T cells play a crucial role in the adaptive immune response against acute virus infections. The extensive diversity of T cell receptors (TCRs) presents a complex challenge for understanding its implications in immune responses. Investigating the dynamics of the immune response to acute virus infection is inherently more complex compared to studying vaccine responses, but it offers a more comprehensive view on the subject matter.

Methods

Therefore, we used an immunosequencing approach to investigate acute viral infections in a murine model system. Specifically, we analyzed the TCRβ repertoire to identify dissimilarities in the immune response of BALB/c mice against different variants of tick-borne encephalitis virus (TBEV), which differ by a few amino acid substitu

SUBMITTER: Salnikova MA 

PROVIDER: S-EPMC12756428 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature