Translating <i>in vitro</i> gut microbiota models to human context: compositional correlations under dietary fiber intervention.

ABSTRACT:

Introduction

Large interindividual variation in human gut microbiota composition and its response to interventions limits the development of novel microbiota-targeted supplements. In vitro models reflecting this interindividual variation and predicting individual in vitro microbiota responses would allow for the assessment of the potential efficacy of such interventions.

Methods

Here, we investigated whether in vitro microbiota modulation by a dietary fiber mixture is translatable to in vivo microbiota outcomes. A 12-week double blind, randomized, placebo-controlled, crossover study with a dietary fiber mixture of acacia gum (AG) and carrot powder was performed in healthy volunteers (N = 54, 45-70 years, BMI 27.3 ± 1.4 kg/m²). The in vitro pla

SUBMITTER: Hoevenaars FPM 

PROVIDER: S-EPMC12756460 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature