Cecal growth factors promote enteric neurosphere formation and hindgut colonization in the avian model.

ABSTRACT:

Introduction

The enteric nervous system (ENS) originates from neural crest cells (NCC) that migrate along the developing gut and differentiate into enteric neurons and glial cells. Disruption of ENS development leads to neurointestinal disorders, such as Hirschsprung disease (HSCR), characterized by aganglionic segments in the distal colon. ENS-derived stem cells (ENSCs), capable of forming multipotent neurospheres, have shown great promise for cell-based therapies. However, optimizing the cell culture conditions and understanding the molecular signals that regulate ENSC development remain unclear. Given the conserved developmental interactions between NCCs and the gut mesenchymal environment in mammals and birds, the avian embryo provides a valuable model for investigating ENS dev

SUBMITTER: Soos A 

PROVIDER: S-EPMC12756466 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature