Assessment of parent-of-origin effects in linkage analysis of quantitative traits.

ABSTRACT: Methods are presented for incorporation of parent-of-origin effects into linkage analysis of quantitative traits. The estimated proportion of marker alleles shared identical by descent is first partitioned into a component derived from the mother and a component derived from the father. These parent-specific estimates of allele sharing are used in variance-components or Haseman-Elston methods of linkage analysis so that the effect of the quantitative-trait locus carried on the maternally derived chromosome is potentially different from the effect of the locus on the paternally derived chromosome. Statistics for linkage between trait and marker loci derived from either or both parents are then calculated, as are statistics for testing whether the effect of the maternally derived locus is eq

SUBMITTER: Hanson RL 

PROVIDER: S-EPMC1275649 | biostudies-literature | 2001 Apr

REPOSITORIES: biostudies-literature