Contribution of structural and functional MRI in predicting response to motor training in multiple sclerosis.

ABSTRACT:

Background

Aerobic training is a promising rehabilitation strategy in multiple sclerosis (MS). However, individual responses to exercise vary.

Objectives

To assess whether baseline demographic, clinical, and MRI features in MS patients predict response to aerobic or non-aerobic training.

Methods

Eighty-eight MS patients were randomized to 24-session aerobic (n = 43) or non-aerobic (n = 45) training over 2-3 months. Responders were defined by a ⩾ 21.6 meters improvement in the 6-minute walking test. Baseline assessments included global disability, fatigue, walking speed, peak oxygen consumption, and structural/functional MRI (lesion load, brain volumetrics, cortical thickness, white matter (WM) microstructural integrity, and resting-state functional conne

SUBMITTER: Morozumi T 

PROVIDER: S-EPMC12756515 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature