GATAD2B promotes ovarian cancer malignant progression via MYC/CD47 Axis.

ABSTRACT: This study elucidates the biological function of GADAT2B and its underlying mechanism in ovarian cancer.The results of our experiment showed that GATAD2B highly expressed in OC tissues, which was associated with a poor prognosis. METTL3 regulated the expression of GATAD2B in OC cells via m6A methylation. And it was unveiled that up-regulation of GATAD2B significantly promoted OC growth, invasion, migration of and suppressed the tumor cell apoptosis. After transfected with sh-GATAD2B, the OC cells were just the reverse in behavior. Additionally, GATAD2B played a crucial role in regulating CD47 expression via the MYC-mediated pathway, and the further experiments showed that GATAD2B and MYC were co-localized on tumor cell membrane. The in vivo and in vitro experiments showed an important role

SUBMITTER: Guo T 

PROVIDER: S-EPMC12756553 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature