Mpox virus OPG175 negatively regulates viral replication by controlling Wnt signaling.

ABSTRACT: Mpox virus (MPXV) infection exhibits different case fatality rates and symptoms depending on its clade. However, there has been insufficient molecular biological analysis of the differences between clades. Here, we investigated whether clades can be distinguished by focusing on the expression of MPXV genes. The replication efficiency of MPXV clade IIb, responsible for the 2022 mpox outbreak, was lower than that of clades Ia and IIa. We found that OPG175 was highly expressed in MPXV clade IIb-infected cells. Suppression of OPG175 expression significantly increased the infectious titer of MPXV, whereas OPG175 overexpression significantly decreased it. We also found that OPG175 overexpression enhanced the expression of Wnt signaling-related genes, and activation of Wnt signaling decrea

SUBMITTER: Nakata Y 

PROVIDER: S-EPMC12756559 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature