Complementary roles of the human perirhinal and the entorhinal cortex in the hippocampal retrieval of episodic memory.

ABSTRACT: Episodic memory involves the representation of memories shared across a global context as well as that of unique events that occurred within it. To examine how parahippocampal subregions support this balance, we had participants encounter multiple objects in each building of a virtual environment and later asked them to recall the building associated with each cued object during fMRI scanning. Across the MTL, objects from the same building showed greater representational similarity than those from different buildings, indicating the integration of contextually associated memories. This effect was observed only for task-relevant contexts (i.e., buildings but not corners). Higher similarity in the EC and lower similarity in the PrC were associated with performance, and integration in the EC

SUBMITTER: Kim JS 

PROVIDER: S-EPMC12756634 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature