Dietary manganese, type 2 diabetes, and cardiovascular disease: A UK Biobank cohort study and meta-analysis of over 270,000 individuals.

ABSTRACT:

Objectives

To examine the association of dietary Manganese (Mn) intake with type 2 diabetes (T2D) incidence, total cardiovascular disease (CVD), and CVD mortality by analyzing data from the UK Biobank and conducting a meta-analysis of available prospective cohorts.

Design

Prospective analysis of a primary cohort with a dose-response meta-analysis of prospective cohorts.

Setting

The UK Biobank cohort and the meta-analysis of prospective cohorts.

Participants

UK Biobank participants aged 40-69 years at baseline were enrolled between 2006 and 2010 and followed until December 2022. We included 165,194 participants in T2D analytic cohort and 164,111 individuals in CVD analytic cohort. Our systematic review and meta-analysis of six studies comprised over 270,000 part

SUBMITTER: Gebretsadik GG 

PROVIDER: S-EPMC12756635 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature